Surgical techniques for the articular cartilage repair: literature review and meta-analysis

Objective. To evaluate the clinical efficacy and safety of implementing extracellular matrix (ECM), Autologous Matrix Induced Chondrogenesis (AMIC), adipose tissue derived mesenchymal stem cell (AD-MSCs), as well bone marrow cells (BM-MSCs) for treating osteochondral defects knee joint talocrural one. Methods. Investigating by facilities PubMed, Embase manual searches, implemented from 2018 till January, 2022. There have been included articles with І‒ІV level evidence, studying over 0.5 сm2, at least one-year duration monitoring more than 10 patients, defining scores on VAS (Visual Analogue Scale), Tegner Activity Scale, FAOS (Foot Ankle Outcome Score). The results were evaluated after 1–2, 3–5 5 years-period monitoring. Meta-analysis was applied RStudio. Results. 14 investigations 720 patients incorporated. ECM, AMIC, AD-MSCs BM-MSCs represented significantly better functional outcomes in comparison stimulation procedures (MSP) VAS, scales. Patients treated according to AMIC+BMAC (bone aspirate concentrate) method showed compared standard AMIC technique. rate unsuccessful manipulations followed revision operations MSP group is higher others 4 or years obtained a long-term investigation no deterioration more. Conclusions. Modern methods cartilage repair creation microfractures microdrilling provide quality regeneration, results, fewer complications, rates return activity. Future studies should be longer-lasting include representative populations determine these methods.